TWIN4EarLiStAge
Research Focus
A central aspect in aging concerns the extent to which early-in-life events can determine the aging process. For instance, stress-inducing conditions during development can positively impact healthspan and lifespan. However, the location, timing and cellular effects of such events are largely unknown. The coordinator (University of Crete) wishes to build on previous knowledge on signaling functions of Reactive Oxygen Species (ROS) which, when activated during early life stages, have protective effects. By partnering with two prominent Centers in Aging Research, we plan to identify the critical time window and specific mechanisms which are triggered in response to stressors to contribute to lifespan determination and apply this knowledge to prolong life and protect against age-related pathologies.
